Morning brew at risk

Strange brew: assessing risk of chemical mixtures.

Intravenous administration of the anticancer drug, cis-dichlorodimmineplatinum (CDDP) leads to tumour regression in 50% of patients with advanced ovarian cancer (Gershenson et al, 1981; Adams et al, 1984). The number of treatment failures, coupled with the drug-induced host toxicities in this condition, have prompted studies on the human tumour stem cell assay (Salmon & Von Hoff; 1982) in which...

Richard Hugh Brew

year. He was born at Ballyvaughan Rector}/, Co. Clare, the only son of Richard St. John Brew, an officer who died at the early age of 27, and was educated at the medical schools of Dublin and at Edinburgh, where in 1884 he obtained his diplomas of L.R.C.P., L.R.C.S., and L.M. Edin. After a short assistantship at Chesham, he practised in Birmingham, but moved to Chew Magna shortly after his marr...

Home-Brew the Blockbuster

Photo A. The six-meter Blockbuster. A lthough I enjoy ragchewing, DX-chasing, contesting, satellite work, and just about every conceivable aspect of amateur radio, the activity I enjoy most of all is home-brewing, especially home-brewing with a purpose. This article describes a reasonably ambitious effort which was precipitated by a very distinct purpose: I wanted to become more competitive in ...

Chemical Brew of Criminal Behavior,The

Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents†

BACKGROUND There is increasing evidence for genetic effects on the hypothalamic-pituitary axis system. More than one gene is likely to moderate corticoid-mediated activity. AIMS To investigate whether the brain-derived neurotrophic factor (BDNF) polymorphism (rs6265, Val66Met) is associated with morning waking salivary cortisol and moderates the corticoid-mediated risk for subsequent depressi...